Patients and study design
Patients who received pediatric LT from 2006 to 2019 at RenJi Hospital, Shanghai Jiaotong University School of Medicine were included in this study. Patients with loss of follow-up or death within the first month after operation were excluded from this study. All the patients were follow-up until the study end date of December 2019. All pediatric LT in this study received approval from Shanghai Jiaotong University School of Medicine, Renji Hospital Ethics Committee. No organs from executed prisoners were transplanted and reported in this study. This retrospective study was performed following the declaration of Helsinki guidelines.
To analyzed risk factors of switching IS drugs after pediatric LT, patients were divided into two groups: patients with switching IS drugs and patients without switching IS drugs. Data of recipients were collected from our maintained database of liver transplantation. Patient characteristics including demographics, comorbidities, pre-operative lab values, outcome based on post-transplantation events were compared between the two groups.