Authors’ Contribution
T.C., S.S., C.C., and T.B. carried out the experiment. T.B., S.J., M.A.,
M.S, and C.A. conceived and planned the experiments. T.B. and M.S. wrote
the manuscript with support from A.S., M.A. and C.A. T.B., T.C., S.S,
C.C, P.P. and W.M. recruited the participants. T.C., S.S., C.C. and T.B.
prepared the samples. M.W. prepared the HBEC samples and ALI culture.
T.B., A.S. and C.A. supervised the study.
REFERENCES
1. Diamant Z, Vijverberg S, Alving K, et al. Toward clinically
applicable biomarkers for asthma: An EAACI position paper.Allergy. 2019;74(10):1835-1851.
2. Boonpiyathad T, Sozener ZC, Akdis M, Akdis CA. The role of Treg cell
subsets in allergic disease. Asian Pac J Allergy Immunol.2020;38(3):139-149.
3. Boonpiyathad T, Sozener ZC, Satitsuksanoa P, Akdis CA. Immunologic
mechanisms in asthma. Semin Immunol. 2019;46:101333.
4. Marques CR, Costa RS, Costa GNO, et al. Genetic and epigenetic
studies of FOXP3 in asthma and allergy. Asthma Res Pract.2015;1:10.
5. Kim BS, Kim IK, Park YJ, et al. Conversion of Th2 memory cells into
Foxp3+ regulatory T cells suppressing Th2-mediated allergic asthma.Proc Natl Acad Sci U S A. 2010;107(19):8742-8747.
6. Boonpiyathad T, Capova G, Duchna HW, et al. Impact of high-altitude
therapy on type-2 immune responses in asthma patients. Allergy.2020;75(1):84-94.