Linear pairs in highly interacting pathogen proteins and host
proteins
Several previous studies have shown that essentiality and pathogen
fitness are correlated with high number of interactions (78, 79).
Therefore, the number of DLPs and MLPs in the top 10 highly interacting
pathogen proteins and host proteins were examined and are listed in
Table 6 and Table 7 respectively. The top 10 highly interacting pathogen
proteins were of viral origin and predominantly formed MLPs, indicating
that local sequence similarities predominate the mimicry of host
proteins by pathogens. Among host proteins, a few had a very high number
of DLPs. As shown in Table 7, Nuclear factor NF-kappa-B p105 subunit was
a part of 491 while Cellular tumor antigen p53 was a part of 180 DLPs.