Figure1. Schematic illustration of the hypothesis. (A,B) Bilateral GPi lead location, globus pallidus internus (light blue), globus pallidus externus (orange), and putamen (pink), Volume of tissue activated (VTA) (red for negative and blue for positive) are shown for reference; (A) Volume of tissue activated (VTA) in the initial programming setting, L-GPi (3+;0-), R-GPi (C+;8-), 90 us pulse width, 90 Hz frequency, and 1.3 amplitude ; (B) VTA in the second programming setting: L-GPi L-GPi (3+;0-), R-GPi (C+;8-), 90 us pulse width, 90 Hz frequency, and 2.5 amplitude. (CI) Multiple parallel pathways connect different parts of cortex, Striatum and thalamus. Stimulation of a target (e.g. anteromedial GPi) as a member of these multiple parallel pathways, would spread through all different pathways related to anteromedial GPi and subsequently these pathways would response to the stimuli in a term of resynchronization as an embodiment. (CII) The response of can be varied in respect to pathways physiological condition including different stimulation thresholds and occurrence of neuroplasticity.