3.2.3 The proportion of PNH clones decreased
The ratio of CD59- peripheral blood granulocytes and erythrocytes before and after chemotherapy was detected by flow cytometry. The results showed that the proportion decreased after chemotherapy, but the difference was not statistically significant. The proportion of CD59- granulocytes and erythrocytes in 16 patients decreased from 75.05 ± 18.33% and 57.75 ± 16.28% to 66.53± 20.69% and 49.18± 14.27% (p = 0.072 and p = 0.053), respectively. However, there were still 3 patients (3/20, 15.00%) whose granulocyte and erythrocyte CD59- ratios did not decrease as expected. Consistent with the above results, anemia and blood transfusion in these 3 patients did not improve.