3.4 Safety
No deaths occurred during chemotherapy. The most common adverse reactions during chemotherapy were infection (14/20, 70.00%), nausea (12/20, 60%), vomiting (11/20, 55%) and fatigue (9/20, 45%). Almost all patients had myelosuppression after chemotherapy. Among them, 14 patients had agranulocytosis with fever, and their body temperature fluctuated between 38.5 and 39.8°C. The main infections were upper respiratory tract infection in 4 patients, pneumonia in 3 patients, sepsis in 2 patients, oral infection in 1 patient, perianal infection in 2 patients, skin herpes in 1 patient, suspected cholecystitis in 1 patient, and local infection in 2 patients. The above adverse reactions resolved after the recovery of hematopoietic reconstitution. The mean duration of myelosuppression was 24.28 (18-52) days, the minimum values of leukocytes and granulocytes were 0-1.29, and the minimum values of platelets were 1-35* 109/L. Two patients had platelet transfusion failure. No patient had complications with severe bleeding symptoms. During chemotherapy, patients were treated with heart- and liver-protecting treatments at the same time, and no serious complications occurred.