Conclusion:
The histomorphology and the immunohistochemical study of the neuroendocrine markers are the basis for the definitive diagnosis of invasive breast carcinoma with neuroendocrine differentiation. But the combined approach with clinical assessment and radiological images aid in the diagnosis. The current diagnostic methods and treatment protocols are similar to other invasive breast carcinomas. Because it has a poorer prognosis than invasive carcinoma of the breast without neuroendocrine tumors, it is important to make the early diagnosis of the neuroendocrine component. Hence, larger studies are needed to better understand the biological features of invasive breast carcinoma with neuroendocrine differentiation.