Key message
There is paucity of data on peanut OIT long-term effects and quality of life impact. PPOIT induces sustained unresponsiveness that persists to 3-years post-treatment in a high proportion of treated patients, and leads to long-lasting improvement in health-related quality of life, supporting previous findings from a proof-of-concept randomized trial. PPOIT provides lasting benefits for children with peanut allergy, offering an approach to induce long-term sustained unresponsiveness and improve health-related quality of life.