Analytical technique ELISA ELISA ELISA ECLIA CLIA CLIA LFI
Epitope Anti-RBD Anti-S1 Anti-N Anti-N Anti-N Anti-S1/S2 Anti-RBD+
Antibody subtype IgG IgG IgG IgG/IgM IgG IgG Pan-Ig
Manufacturer In-house Euroimmun Epitope diagnostics Roche diagnostics Abbott DiaSorin Bühlmann
Numbers of patients 197 201 197 188 188 188 157
True positives 127 140 98 133 122 131 95
False negatives 21 11 50 12 23 14 13
False positives 2 4 17 3 0 1 1
True negatives 47 46 32 40 43 42 48
Sensitivity (percent; 95%CI) 85.8 (91.0, 79.1) 92.7 (87.3, 96.3) 66.2 (58.0, 73.8) 91.7 (86.0, 95.6) 84.1 (77.2, 89.7) 90.3 (84.3, 94.6) 87.9 (80.3, 93.4)
Specificity (percent; 95%CI) 95.9 (86.0, 99.5) 92.0 (80.8, 97.8) 65.3 (50.4, 78.3) 93.0 (80.9, 98.5) 100 (91.8, 100) 97.7 (87.7, 99.9) 97.9 (89.2, 100)