Introduction:
Sarcoidosis is a systemic disease of unknown etiology characterized by
multiple non caseating granulomas, particularly in lungs, lymph nodes,
skin and kidney. “Sarcoid‑like reaction” (SLR) are non caseating
epithelioid granulomas, found in association with many tumors without
systemic manifestation of sarcoidosis. But, the distinction between SLR
and systemic sarcoidosis may at times be difficult. Increased risk of
neoplasia in systemic sarcoidosis was reported. Indeed, sarcoidosis can
occur in solid and hematological malignancies before, during, or after
the onset of the disease (1-3). Herein, we report two cases of renal
cell carcinoma associated with systemic sarcoidosis.