Conclusions:
We report a rare association between renal cancer and sarcoidosis.
Because of its rarety, physiopathological link between these two
diseases and prognostic value of granulomatosis remains unclear. We
propose close monitoring of the incidence of renal neoplasia through a
prospective study of patients with sarcoidosis to better understand and
characterize this association. On the other hand, before claiming an
association between renal cancer and sarcoid-like reaction, the other
causes such tuberculosis or sarcoidosis must be excluded by a careful
clinical history, diagnostic tests and pathologic examination.
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AUTHOR CONTRIBUTIONS :
MK and HJ : wrote the first draft of the article, participated in
collecting patient data (clinical history), reviewed the literature,
interpreted the clinical findings. IM, FBH, LR, LBF and MKZ : critically
reviewed and edited drafts. AZ and SH : were the pathologists.
ACKNOWLEDGMENTS :
We are indebted to Drs Hela Jebali, ikram mami, lamia rais, lilia ben
fatma and karim zouaghi for their active and thoughtful contribution to
the management of the patient. We also thank Dr Alia zhini and dr slim
haout for having interpreted the patient biopsy.
CONFLICT OF INTEREST :
We have no financial interest or conflict of interest in association
with this work.
ETHICAL APPROVAL :
The two patients have given their written informed consent to publish
this cases including publication of images.
This manuscript has not been published previously and is not being
considered for publication by another journal.
KEY CLINICAL MESSAGE :
Granulomatosis can be observed in cancer patients. Granulomatosis
reaction associated with tumor has been designated as sarcoid-like
reaction. On the other side, very few cases of association of systemic
sarcoidosis and neoplasia have been reported.
CORRESPONDING AUTHOR :
Meriam khadhar : khadhar-meriam@hotmail.fr