Introduction:
Sarcoidosis is a systemic disease of unknown etiology characterized by multiple non caseating granulomas, particularly in lungs, lymph nodes, skin and kidney. “Sarcoid‑like reaction” (SLR) are non caseating epithelioid granulomas, found in association with many tumors without systemic manifestation of sarcoidosis. But, the distinction between SLR and systemic sarcoidosis may at times be difficult. Increased risk of neoplasia in systemic sarcoidosis was reported. Indeed, sarcoidosis can occur in solid and hematological malignancies before, during, or after the onset of the disease (1-3). Herein, we report two cases of renal cell carcinoma associated with systemic sarcoidosis.