Introduction
Acute thrombosis in patients with an inherited bleeding disorder (BD) represents a need to balance treating a thrombus with anticoagulation while maintaining adequate hemostasis 1. This is important in managing a critical thrombus such as a cerebral sinus venous thrombosis (CSVT), especially following trauma, when the risk of intracranial hemorrhage (ICH) is significantly heightened2,3. In children with BDs, there are no standard guidelines that direct management of thrombosis4. Literature regarding the treatment of CSVT is variable, with studies demonstrating good neurological outcomes and thrombus resolution without anticoagulation therapy as well as studies indicating CSVT propagation in over 1/3 of children not treated with anticoagulation therapy 5-7. Here we present the management and outcome of four children with inherited BDs who developed trauma related CSVT. A summary of lab values, management, complications, and outcomes are provided in Table 1.