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\begin{document}

\title{Mini-Hyper CVD+CRIB (Condensed Rituximab, Inotuzumab Ozogamicin, and
Blinatumomab) for Refractory Pediatric B-ALL}



\author[1]{David McCall}%
\author[2]{Elias Jabbour}%
\author[1]{Michael Roth}%
\author[1]{Cesar Nunez}%
\author[1]{Branko Cuglievan}%
\affil[1]{Department of Pediatrics The University of Texas MD Anderson Cancer Center Houston Texas}%
\affil[2]{The University of Texas MD Anderson Cancer Center Department of Leukemia}%


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  \date{May 17, 2024}


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\begin{abstract}
Relapsed or refractive pediatric B-Acute Lymphoblastic Leukemia (B-ALL)
patients have high rates of toxicities and relapse, and novel therapy is
needed. We present a case of a 5-year-old male with high-risk B-ALL that
was refractive to several re-induction regimens. He was put into
MRD-negative remission after re-induction with chemotherapy plus
overlapping rituximab, inotuzumab ozogamicin and blinatumomab, termed
Mini-Hyper-CVD plus CRIB. This was well tolerated, and he received his
transplant and engrafted with no significant infections, toxicities, or
sinusoidal obstruction syndrome. This is the first reported use in
pediatrics of a condensed sequential immunotherapy/chemotherapy regimen
in a pediatric leukemia patient.%
\end{abstract}%



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\verb`miniCVD_PBC_Brief Report.docx`  available at \url{https://authorea.com/users/436622/articles/573242-mini-hyper-cvd-crib-condensed-rituximab-inotuzumab-ozogamicin-and-blinatumomab-for-refractory-pediatric-b-all}

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