Whipple's endocarditis is a rare culture-negative endocarditis caused by
Tropheryma whipplei, an intracellular gram-positive organism. Here, we
present a case of a 60-year-old male who presented with transient
ischemic attack and was found to have an aortic valve mass. Following
successful excision, histopathologic assessment of the lesion was
consistent with calcified amorphous aortic tumor, a rare non-neoplastic
hamartomatous mass of the heart. However, 16s rRNA and 18s rRNA
sequencing detected Tropheryma whipplei, and the diagnosis of Whipple's
endocarditis was made.