Introduction
Whipple’s disease is a rare multi-system illness that classically presents with gastrointestinal symptoms, polyarthropathy, and central nervous system involvement in later stages [1]. Whipple Endocarditis is a rare cause of culture-negative subacute endocarditis. The first report of T. whipplei isolated from the aortic valve of a patient with blood-culture negative endocarditis was in 2000 [2]. Since then, 170 cases have been reported in the literature. It is not uncommon for Whipple endocarditis to present with arthralgia and heart failure without the classic features of Whipple’s disease. The average age of presentation is 57 years, with male sex predominance. Valvular lesions most commonly involve the aortic valve, but multiple valves can also be infected [3].
On the other hand, calcified amorphous tumor (CAT) is a rare non-neoplastic hamartomatous mass of the heart. The majority of reported cases involve the mitral valve, with only a few reported cases arising from the aortic valve. Pathologically, these tumors are described as nodular calcium deposits with a background of fibrous tissue and chronic inflammatory cells [4]. Clinically, most patients are asymptomatic, but about 56% have obstructive symptoms, embolization, and/or syncope [5].