MME supports connections to knowledge and model organism resources
MME connects to three databases that provide additional utility to the gene discovery scientific community and these databases are considered “Connected Knowledge Sources,” or “Functional Study Node”, specialized MME endpoints that go beyond the initial MME design of patient-patient matchmaking (Figure 2 ). PubCaseFinder helps users identify any existing case reports for candidate genes by using phenotype-based comparisons (PRODUCTION: REFERENCE APPEARS IN THE SAME SPECIAL ISSUE (Fujiwara et al., 2022, 2018) ). To facilitate important downstream translational research using in vitro and in vivo models (Boycott et al., 2020; Wangler et al., 2017) , MME connects to two additional databases; Monarch Initiative and ModelMatcher. The Monarch Initiative (Shefchek et al., 2019) , supports patient-disease model matches (Mungall et al., 2015) , by effectively matching patient phenotype profiles with a potentially existing relevant disease model. ModelMatcher (PRODUCTION: REFERENCE APPEARS IN THE SAME SPECIAL ISSUE (Harnish et al., 2022) ) facilitates cross-disciplinary collaborations as part of a global effort to decrease the time to translational and therapeutic research by connecting scientists and other stakeholders who have interest in the same or orthologous gene (Neff, 2021) .