1 | INTRODUCTION
A comprehensive survey of deep coral reefs in the high seas showed that policymakers should give more attention to protection of ocean ecosystems and marine mammals [1, 2]. Due to a linkage with sources of sustainable food, energy, materials, biomedicine, and many others, it should be a priority attention from the United Nations for the future of this global ecosystem [3]. Currently, ocean economy is accelerating development in the globe and has become a vital support for human sustainable development. As important biomedical resources, drugs from marine organisms have long been used and exhibit unique advantages in clinical practices. Hence, it is a great task to protect and develop ocean resources and prevent and control ocean pollution since some marine compounds are also valuable tools in biomedicine and clinical applications [4, 5].
Major marine natural products (MNPs) and organisms include sea urchin, sea squirts or ascidians, sea cucumbers, sea snake, sponge, soft coral, marine algae, and microalgae. As vital biomedical resources for the discovery of marine drugs, bioactive molecules, and agents for treatment of infectious diseases and major non-communicable diseases (mNCDs), MNPs have many bioactive potentials. This article discusses the studies of MNPs as huge, novel, and promising biomedical resources for anti-infection of coronavirus (SARS-CoV-2 and its variants) and related cardiovascular disease (irCVD) as well as possible mechanisms linked to human immunity.