2.2.2 Remedial dosing strategies
Six remedial strategies were developed considering their clinical feasibility and our previous studies20. Remedial strategies are the action patient will take when they remember their missed dose. Remedial strategies refer to actions that patients will take when they remember their missed dose. As edoxaban tablets are divisible, we included a half dose in our remedial strategy to provide a more precise approach. We tested both the current recommendations from the EHRA guide and our developed remedial strategies. Our remedial strategy is similar to our previous study in rivaroxaban, which are shown in Figure 2 and detailed below 20:
Strategy A: skip the full delayed dose and take the next dose as schedule.
Strategy B: take the full delayed dose immediately and take the next dose as schedule.
Strategy C: take a half delayed dose immediately and take the next dose as schedule
Strategy D: take a full delayed dose immediately followed by a half dose at the next scheduled time, and then resume the regular dosing regimen.
Strategy E: take one and a half delayed doses immediately, skip the next scheduled dose, and then resume the regular dosing regimen.
Strategy F: take a double of delayed dose, skip the next scheduled dose, and then resume the regular dosing regimen.
EHRA guide: take the delayed dose if less than 12 h late; otherwise, skip the delayed or missed dose and administer the next dose at the scheduled time.