Results:
Forty-five patients enrolled in the study, 21 completed ABPMs. Fifteen
patients (33%, 95% CI: 20-49%) developed AKI at least once. Thirteen
(29%, 95% CI: 16-44%) had hyperfiltration, and 11 (24%) had abnormal
proteinuria and/or albuminuria. Prevalence of HTN based on clinic
measurements was 42%. In the 21 ABPM patients, 14 had abnormal results
(67%, 95% CI: 43-85%) with the majority (11/21) demonstrating
abnormal nocturnal dipping pattern. .
Conclusions :
Among children with ALL, there is a high prevalence of past AKI. The
presence of hyperfiltration, proteinuria and/or albuminuria at 1-5 years
after ALL diagnosis suggest real risk of developing CKD over time. There
is a high prevalence of HTN on casual BP readings and even higher
prevalence of abnormal ABPM in this group. The high prevalence of
impaired nocturnal dipping by ABPM indicates an increased risk for
future cardiovascular or cerebral ischemic events.