Definitions
AKI was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO), modified to include only serum creatinine26. CKD was defined as GFR < 90ml/min/1.73m2, CKD stage 2 as GFR 60-89ml/min/1.73m2, CKD stage 3 as GFR 30-59ml/min/1.73m2, CKD stage 4 as GFR 15-29ml/min/1.73m2, and CKD stage 5 (end stage renal disease) as GFR < 15 ml/min/1.73m2 for greater than 3 months respectively27. Renal hyperfiltration was defined as GFR > 2 SD above mean GFR for age and gender28,29. Proteinuria was defined as urine protein/creatinine ≥0.2mg/mg and albuminuria as urine microalbumin/creatinine > 30mg/g.
Based on clinic BP measurements, all resting BP values were averaged and compared to age, sex, and height normal:22 normal BP was defined as BP < 90th percentile, elevated BP as BP ≥ 90th percentile to <95th percentile, stage 1 hypertension as BP ≥ 95th percentile to <95th percentile +12mmHg, and stage 2 hypertension as BP ≥ 95th percentile +12mmHg.
In patients who completed ABPM, HTN was defined as either mean SBP and/or mean DBP ≥ 95th percentile for age, gender, and height.30 Night-day mean arterial pressure (MAP) ratios were calculated and dipping pattern was defined as follows: <0% reverse dippers, ≥0 and <10% non-dippers, ≥10 and < 20% normal dippers, and ≥ 20% extreme dippers.31
ALL risk groups were defined using the subject’s treatment protocol, which is assigned early in treatment, based on a combination of several factors: age at diagnosis, presenting white blood count, cytogenetics, and response to therapy. Tumor lysis syndrome (TLS) was defined per Cairo-Bishop definition of laboratory TLS.32