Trial design
Following informed consent of all eligible participants at the initial
clinic visit, randomization was achieved using opaque envelopes as a
method of allocation concealment. Since this was a non-blinded trial,
the CGM sensor to be used was clearly visible to both the study
participant and research staff. The participants were allocated to the
unblinded study group (Freestyle Libre) or the blinded group (Freestyle
Libre Pro). The flow of the study clinic visit schedule is shown in
Figure S1. There were 4 scheduled clinic appointments for all
participants, and GDM was routinely screened for between 24-28 weeks
with the 75-g 3- point oral glucose tolerance test (OGTT)18 (Figure S1).