INTRODUCTION
IgG4-related disease (IgG4-RD) is an immune-mediated chronic
inflammatory disease that progresses to fibrosis. It is a multisystemic
disease with involvement of secretory glands and kidney etc. It usually
has a subacute course and is frequently observed in middle-aged and
older male population. The pathogenesis of IgG4-RD is still unclear but
elevated IgG4 levels and the good response of IgG4-RD patients to
treatment with rituximab (B-cell depletion treatment), suggest a role of
the humoral immune system in the pathogenesis of IgG4-RD Glucocorticoids
and rituximab used in the treatment of the disease. Early diagnosis,
treatment and follow-up are important for prognosis and recurrence of
the disease (1-4) (Table 1). In our case, we evaluated a patient who had
arthritis, pain, itching, tearing, redness, and referred to our clinic
with impairment in renal function tests from an external center.