INTRODUCTION
IgG4-related disease (IgG4-RD) is an immune-mediated chronic inflammatory disease that progresses to fibrosis. It is a multisystemic disease with involvement of secretory glands and kidney etc. It usually has a subacute course and is frequently observed in middle-aged and older male population. The pathogenesis of IgG4-RD is still unclear but elevated IgG4 levels and the good response of IgG4-RD patients to treatment with rituximab (B-cell depletion treatment), suggest a role of the humoral immune system in the pathogenesis of IgG4-RD Glucocorticoids and rituximab used in the treatment of the disease. Early diagnosis, treatment and follow-up are important for prognosis and recurrence of the disease (1-4) (Table 1). In our case, we evaluated a patient who had arthritis, pain, itching, tearing, redness, and referred to our clinic with impairment in renal function tests from an external center.