A German study explained the effect of centromedian thalamic nucleus deep brain stimulation by using probabilistic tractography in 7 TS patients \citep{Andrade_2020}. They highlighted that the tic reduction following DBS was related to the degree of stimulation-dependent connectivity between the centromedian thalamic nucleus and the pre-supplementary motor area. Conversely, non-responders had more active fibers that project into non-motor cortical areas.