There is ongoing debate around the most relevant target for DBS in GTS, the commonly accepted view being that different structures within a common basal ganglia-thalamo-cortical network may serve as potential targets. In a retrospective study using MRI tractography in 21 patients, Avecillas et al. investigated the basal ganglia-thalamo-cortical networks associated with tics and obsessive compulsive behaviors (OCB) improvement in patients treated with either anteromedial globus pallidus (amGPi) or thalamic ventral-oralis complex / centromedian (Vo/CM) DBS \citep{Avecillas_Chasin_2023}. The networks associated with clinical improvement of tics consisted of a limbic pallidothalamic network for the amGPi target, and the premotor thalamocortical network for the thalamic target, both of which being part of a larger “limbic-motor interface network”. Notably, analysis of the volume of tissue activated by DBS in non-responders showed that the stimulation missed the tracts associated with this specific network. This study reinforces the idea that stimulating this network either at its origin (amGPi), or terminal fields (Vo) can lead to substantial tic improvement. Improvement in OCB was related to the connectivity between the dorso-medial prefrontal cortex (dmPFC)/dorsal anterior cingulate (dACC) and CM. The fact that tics and OCB improvement may be linked to the stimulation of distinct networks questions the relevance of targeting more than one structure. Najera et al. reported on two patients with severe GTS and OCD who underwent dual-targeting DBS in both the ventral capsule / ventral striatum (VC/VS) for OCD, and posteroventral GPi for tics \citep{Najera_2023}. Both patients experienced sustained improvement in both tics and OCB.