Chronic Complications
Table 2 shows the adjusted rates for chronic complications and
reinterventions. Chronic complication rates were significantly lower in
patients implanted with a leadless VVI pacemaker compared with the
transvenous (adjusted, 4.9%, vs. 7.1%, P<0.0001), driven by
lower device-related complication rates (adjusted 2.6% vs. 5.2%,
P<0.0001). In the time-to-event model, patients implanted with
a leadless pacemaker had significantly fewer overall chronic
complications at 3 years compared with patients implanted with a
transvenous pacemaker (Figure 1A ; unadjusted hazard ratio (HR)
0.73; 95% CI 0.64–0.84, P= <0.0001; adjusted HR 0.68; 95%
confidence interval (CI) 0.59–0.78, P< 0.0001). Unadjusted
chronic complication rates are shown in Appendix Table 3.