CONCLUSION
Only the beginning of the cell biology and molecular genetics is being understood and 60% of the genetic basis of ARS in still unknown. Early diagnose is important due to initiate early treatment hereby reduce the possible effect of the anterior chamber changes and postpone or hopefully avoid blindness. Because of the high incidence of glaucoma, it is crucial to follow the patients frequently and monitor the intraocular pressure and the appearance of the optic nerve. Likewise, it is important to initiate early treatment of dental and facial abnormalities to improve functional and aesthetic outcome. As the care of the patients is complex it is advisable to have highly specialized multidisciplinary team to diagnose and treat this patient group.