Xenotransplantation ALL Animal Models
Since the culture system cannot replicate the complex interaction
between leukemia cells and the bone marrow microenvironment, it is very
difficult to culture and expand clinically aggressive patient-derived
leukemia cells in vitro . The rate of cancer metastasis and cell
characteristics may change depending on the culture environment. To
overcome these limitations, researchers transplanted primary ALL cells
and cell lines into immunodeficient mice and developed mouse xenograft
models. The establishment of xenograft models is essential to study the
molecular mechanisms of human leukemia and to improve treatment options
by simulating human disease in animals for a more extensive evaluation
of human ALL.