Xenotransplantation ALL Animal Models
Since the culture system cannot replicate the complex interaction between leukemia cells and the bone marrow microenvironment, it is very difficult to culture and expand clinically aggressive patient-derived leukemia cells in vitro . The rate of cancer metastasis and cell characteristics may change depending on the culture environment. To overcome these limitations, researchers transplanted primary ALL cells and cell lines into immunodeficient mice and developed mouse xenograft models. The establishment of xenograft models is essential to study the molecular mechanisms of human leukemia and to improve treatment options by simulating human disease in animals for a more extensive evaluation of human ALL.