Predictors of tacrolimus dose optimization when drug-drug interaction associated with voriconazole in heart transplant recipients

Xiao Huang, ^a,b,1 Ying Zhou, ^a,b,1Jing Zhang, ^c Hongping Xiang, ^a Hao Mei, ^a Li Liu, ^a,b Lu Tong,^c Fang Zeng, ^a,b Yifei Huang,^a,b Hong Zhou, ^a,b,* Yu Zhang,^a,b,*

^aDepartment of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;

^bHubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan 430022, China;

^cDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

¹ These authors have contributed equally to this work.

^*Corresponding author:

Hong Zhou, MD, Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

E-mail address: whxh_zhou@hust.edu.cn.

Yu Zhang, PhD, Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

E-mail address: yu_union@163.com.

The authors confirm that the Principal Investigator for this paper is Xiao Huang and that she had direct clinical responsibility for patients.

Word count: 3699, table count: 2, figure count: 6.