A unique CD27-IgD- B-cells population in the sputum of severe eosinophilic asthma associated with airway autoimmunity
Nadia Suray Tan1*, Manali Mukherjee2*, Sheau Yng Lim3, Angeline Rouers4,5, You Yi Hwang4, Chung Hwee Thiam3 , W.S. Daniel Tan6, Wupeng Liao6 ,W.S. Fred Wong6, Mei Fong Liew1,7, Parameswaran Nair2, Anis Larbi4, De Yun Wang8, Katja Fink4, Veronique Angeli 3,9#, Hui Fang Lim 1,3,7#
*equal contribution; #Co-senior authors
1 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
2 Division of Respirology, Firestone Institute for Respiratory Health, St Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada
3 Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine and Immunology Program, Life Science Institute, National University of Singapore, Singapore
4 Singapore Immunology Network, Agency for Science, Technology and Research A*STAR, Singapore
5 A*STAR ID Labs, Agency for Science, Technology and Research, Singapore
6 Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore
7 Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, National University Health System, Singapore
8 Department of Otolaryngology, Yong Loo Ling School of Medicine, National University of Singapore, Singapore
9 Singapore-Hebrew University of Jerusalem Alliance for Research and Enterprise (SHARE), National University of Singapore