Introduction
Lamotrigine (LTG) is an important anticonvulsant with activity against both focal and generalized onset seizures. [1] However, its use is associated with a significant incidence of adverse cutaneous reactions, mainly if it is used in combination with other therapy. [2] Rash is the most common adverse reaction of this antiepileptic agent and the most common reason for treatment discontinuation as it can be life-threatening. Children under polytherapy have a higher risk of this adverse event. Such cutaneous reactions range from mild rashes to more serious conditions. [3]
Here, we present two cases of severe skin drug reactions that occurred after addition of LTG to the Valproic acid regimen.