REFERENCES
A. M. Shelton, J.-Z. Zhao, Roush RT. 2002. Economic, Ecological, Food Safety, and Social Consequences of the Deployment of Bt Transgenic Plants. Annu. Rev. Entomol. 47 :845–881.
Alvarez MA. 2014. The Antibody 14D9 as an Experimental Model for Molecular Farming. In: . Plant Biotechnol. Heal. Cham: Springer, pp. 111–131.
Cardon F, Pallisse R, Bardor M, Caron A, Vanier J, Ele Ekouna JP, Lerouge P, Boitel-Conti M, Guillet M. 2019. Brassica rapa hairy root based expression system leads to the production of highly homogenous and reproducible profiles of recombinant human alpha-L-iduronidase. Plant Biotechnol. J. 17 :505–516.
Dehdashti SM, Acharjee S, Nomani A, Deka M. 2020. Production of pharmaceutical active recombinant globular adiponectin as a secretory protein in Withania Somnifera hairy root culture. J. Biotechnol.323 :302–312.
Drake PM, Barbi T, Sexton A, McGowan E, Stadlmann J, Navarre C, Paul MJ, Ma JK-C. 2009. Development of rhizosecretion as a production system for recombinant proteins from hydroponic cultivated tobacco. FASEB J.23 :3581–3589.
Drake PMW, Chargelegue DM, Vine ND, Van Dolleweerd CJ, Obregon P, Ma JKC. 2003. Rhizosecretion of a monoclonal antibody protein complex from transgenic tobacco roots. Plant Mol. Biol.
Ele Ekouna JP, Boitel-Conti M, Lerouge P, Bardor M, Guerineau F. 2017a. Enhanced production of recombinant human gastric lipase in turnip hairy roots. Plant Cell. Tissue Organ Cult. 131 :601–610. http://dx.doi.org/10.1007/s11240-017-1309-1.
Ele Ekouna JP, Boitel-Conti M, Lerouge P, Bardor M, Guerineau F. 2017b. Enhanced production of recombinant human gastric lipase in turnip hairy roots. Plant Cell, Tissue Organ Cult. 131 :601–610.
Fox JL. 2012. First plant-made biologic approved. Nat. Biotechnol. 30 :472–472.
Fraissinet-Tachet L, Baltz R, Chong J, Kauffmann S, Fritig B, Saindrenan P. 1998. Two tobacco genes induced by infection, elicitor and salicylic acid encode glucosyltransferases acting on phenylpropanoids and benzoic acid derivatives, including salicylic acid. FEBS Lett.437 :319–323.
Gutierrez-Valdes N, Häkkinen ST, Lemasson C, Guillet M, Oksman-Caldentey KM, Ritala A, Cardon F. 2020. Hairy Root Cultures—A Versatile Tool With Multiple Applications. Front. Plant Sci.
Häkkinen ST, Raven N, Henquet M, Laukkanen ML, Anderlei T, Pitkänen JP, Twyman RM, Bosch D, Oksman-Caldentey KM, Schillberg S, Ritala A. 2014. Molecular farming in tobacco hairy roots by triggering the secretion of a pharmaceutical antibody. Biotechnol. Bioeng. 111 .
Häkkinen ST, Reuter L, Nuorti N, Joensuu JJ, Rischer H, Ritala A. 2018. Tobacco BY-2 media component optimization for a cost-efficient recombinant protein production. Front. Plant Sci. 9 .
Häkkinen ST, Moyano E, Cusidó RM, Palazó J, Teresa M, Ol P, Oksman-Caldentey K-M. 2005. Enhanced secretion of tropane alkaloids in Nicotiana tabacum hairy roots expressing heterologous hyoscyamine-6b-hydroxylase. J. Exp. Bot. 56 :2611–2618.
Halder M, Sarkar S, Jha S. 2019. Elicitation: A biotechnological tool for enhanced production of secondary metabolites in hairy root cultures.Eng. Life Sci. 19 :880–895.
He X, Haselhorst T, von Itzstein M, Kolarich D, Packer NH, Gloster TM, Vocadlo DJ, Clarke LA, Qian Y, Kermode AR. 2012. Production of α-L-iduronidase in maize for the potential treatment of a human lysosomal storage disease. Nat. Commun. 2012 31 3 :1–9.
Holland T, Sack M, Rademacher T, Schmale K, Altmann F, Stadlmann J, Fischer R, Hellwig S. 2010. Optimal nitrogen supply as a key to increased and sustained production of a monoclonal full-size antibody in BY-2 suspension culture. Biotechnol. Bioeng.107 :278–289.
Huet Y, Ele J-P, Aurore E, Katiba C, Michèle Boitel-Conti M, Guerineau F. 2014. Production and secretion of a heterologous protein by turnip hairy roots with superiority over tobacco hairy roots. Biotechnol. Lett. 36 :181–190.
Karimzadegan V, Jalali Javaran V, Shams Bakhsh M, Jalali Javaran M. 2019. The Effect of Methyl Jasmonate and Temperature on the Transient Expression of Recombinant Proteins in Cucurbita pepo L. Mol. Biotechnol. 61 :84–92.
LaCount W, An G, Lee JM. 1997. The effect of polyvinylpyrrolidone (PVP) on the heavy chain monoclonal antibody production from plant suspension cultures. Biotechnol. Lett. 19 :93–96.
Lucht JM. 2015. Public Acceptance of Plant Biotechnology and GM Crops.Viruses 7 :4254–4281.
Madeira LM, Szeto TH, Henquet M, Raven N, Runions J, Huddleston J, Garrard I, Drake PMW, Ma JK-C. 2016. High-yield production of a human monoclonal IgG by rhizosecretion in hydroponic tobacco cultures.Plant Biotechnol. J. 14 :615–624.
Magnuson NS, Linzmaier PM, Gao JW, Reeves R, An G, Lee JM. 1996. Enhanced recovery of a secreted mammalian protein from suspension culture of genetically modified tobacco cells. Protein Expr. Purif. 7 :220–228.
Martínez C, Petruccelli S, Giulietti AM, Alvarez MA. 2005. Expression of the antibody 14D9 in Nicotiana tabacum hairy roots. Electron. J. Biotechnol. 8 :51–57.
Medicago. 2021. Medicago and GSK announce positive Phase 3 efficacy and safety results for adjuvanted plant-based COVID-19 vaccine candidate. https://www.gsk.com/en-gb/media/press-releases/med.
Oksman-Caldentey K-M, Kivela O, Hiltunen R. 1991. Spontaneous shoot organogenesis and plant regeneration from hairy root cultures of Hyoscyamus muticus. Plant Sci. 78 :128–136.
Pham NB, Schäfer H, Wink M. 2012. Production and secretion of recombinant thaumatin in tobacco hairy root cultures. Biotechnol. J. 7 :537–545.
Rage E, Marusic C, Lico C, Salzano AM, Scaloni A, Baschieri S, Donini M. 2020. Optimisation of PD-FcY veterinary antigen secretion from Nicotiana benthamiana hairy roots and purification from the culture medium.Plant Cell. Tissue Organ Cult. 142 :23–39.
Rini Vijayan KP, Raghu A V. 2020. Methods for Enhanced Production of Metabolites Under In Vitro Conditions. Plant Metab. Methods, Appl. Prospect. :111–140.
Scheible W-R, Morcuende R, Czechowski T, Fritz C, Osuna D, Palacios-Rojas N, Schindelasch D, Thimm O, Udvardi MK, Stitt M. 2004. Genome-Wide Reprogramming of Primary and Secondary Metabolism, Protein Synthesis, Cellular Growth Processes, and the Regulatory Infrastructure of Arabidopsis in Response to Nitrogen. Plant Physiol.136 :2483–2499.
Sharp JM, Doran PM. 2001. Strategies for enhancing monoclonal antibody accumulation in plant cell and organ cultures. Biotechnol. Prog.17 :979–992.
Taiz L. 1994. Expansins: Proteins that promote cell wall loosening in plants. Proc. Natl. Acad. Sci. U. S. A. 91 :7387–7389.
U.S. National Library of Medicine. 2022. Search of: plant-derived AND pharmaceuticals - Results on Map - ClinicalTrials.gov.
Vasilev N, Schmitz C, Dong L, Ritala A, Imseng N, Häkkinen ST, van der Krol S, Eibl R, Oksman-Caldentey KM, Bouwmeester H, Fischer R, Schillberg S. 2014. Comparison of plant-based expression platforms for the heterologous production of geraniol. Plant Cell. Tissue Organ Cult. 117 .
Wongsamuth R, Doran PM. 1997. Production of monoclonal antibodies by tobacco hairy roots. Biotechnol. Bioeng. 54 :401–415.