Figure 4. Isorhamnetin restored AngII-induced prolonged APD in
Hl-1 cells.
(A-C) Representative images before and after burst pacing with HL-1
cells spontaneous potentials. (D-F) Representative images of single AP.
Red arrows show abnormal APs. (G) Representative images of merged three
consecutive action potentials from three groups. Quantification of APD:
(H) APD 20; (I) APD 50; (J) APD 90 from three groups. (K) Frequency of
DADs (control, n = 15 from 5 channels; AngII, n = 15 from 5 channels;
AngII+isorhamnetin, n = 15 from 5 channels). **P < 0.01
control vs. AngII by one-way ANOVA with post-hoc test (Tukey);##P < 0.01 AngII vs.
AngII+isorhamnetin by one-way ANOVA with post-hoc test (Tukey).