3.5 Isorhamnetin restored AngII-induced atrial enlargement and
related gene expression in AF model mice
Left atrial enlargement is closely related to structural remodeling. To
confirm the suppressive effect of isorhamnetin on atrial enlargement, an
echocardiography study was performed. LAD was calculated from the B-mode
images (Fig. 5A). Isorhamnetin significantly restored the AngII-induced
enlargement of the LAD (Fig. 5B). However, AngII and isorhamnetin did
not cause significant changes in ejection fraction (EF) and fractional
shortening (FS) compared to the control group (Table 1). In addition,
atrial weight (AW) and body weight (BW) were assessed in all three
groups (Fig. 5C). AngII remarkably increased AW/BW, but this effect was
reversed by isorhamnetin. Moreover, the AngII-induced elevation in the
expression levels of natriuretic peptide B (Nppb ), a cardiac
hypertrophic marker, was significantly reversed by isorhamnetin
treatment (Fig. 5D).