Impact
of isorhamnetin for suppression of electrical and structural remodeling
via CaMKII-RyR2 and TRPC-mediated MAPK pathways in atrial fibrillation
Short running title: Novel therapeutic impact of isorhamnetin for atrial
fibrillation
Kazuhiro Aonuma1,2, DongZhu Xu2,3,
Nobuyuki Murakoshi3, Kazuko Tajiri3,
Yuta Okabe3, Zixun Yuan3, Siqi
Li3, Yoshiko Murakata3, Kenichi
Tominaga2, Akihiko Nogami3, Kazutaka
Aonuma3, Masaki Ieda3, Hiroko
Isoda1,2,4
1School
of Integrative and Global Majors (SIGMA), University of Tsukuba, Japan
2AIST-University
of Tsukuba Open Innovation Laboratory for Food and Medicinal Resource,
University of Tsukuba, Japan
3Department
of Cardiology, Faculty of Medicine, University of Tsukuba, Japan
4Faculty of Life and Environment Science, University
of Tsukuba, Japan.
Address for correspondence: DongZhu Xu, M.D., Ph.D.
Department of Cardiology, Faculty of Medicine, University of Tsukuba,
1-1-1
Tennodai, Tsukuba, Ibaraki 305-8575, Japan
Phone: +81-29-853-3142
Fax: +81-20-853-3143
Email:xu_dongzhu@md.tsukuba.ac.jp
Word count: 5029