4.5 Potential limitations
In this study, the AngII-induced AF mouse model had limitations in its
ability to evaluate arrhythmic substrates related to clinical AF. Other
models, such as myocardial infarction-induced AF and burst
pacing-induced AF, will need to be investigated in future studies.
Furthermore, the application of this study to larger mammals should also
be considered, and an applied study involving patients with AF is
indispensable. Additionally, although no serious side effects of
isorhamnetin have been reported, an appropriate dosage should also be
considered in studies involving humans.