ABSTRACT :
Background :
Three-dimensional echocardiography (3DE) is an emerging method for
volumetric cardiac measurements; however, few vendor-neutral analysis
packages exist. Ventripoint Medical System Plus (VMS3.0+) proprietary
software utilizes a validated MRI database of normal ventricular and
atrial morphologies to calculate chamber volumes. This study aimed to
compare left ventricular (LV) and atrial (LA) volumes obtained using
VMS3.0+ to Tomtec echocardiography analysis software.
Methods :
Healthy controls (n=98) aged 0 to 18 years were prospectively recruited
and 3D DICOM datasets focused on the LV and LA acquired. LV and LA
volumes and ejection fractions were measured using TomTec Image Arena 3D
LV analysis package and using VMS3.0+. Pearson correlation coefficients,
Bland-Altman’s plots and intraclass coefficients (ICC) were calculated,
along with analysis time.
Results :
There was a very good correlation between VMS and Tomtec LV systolic
(r2 = 0.88, ICC 0.89 [95% CI 0.81,0.94]), and
diastolic (r2 = 0.88, ICC 0.90 [95% CI
0.77,0.95]) volumes, and between VMS and Tomtec LA diastolic
(r2 =0.75, ICC 0.89 [95% CI 0.81,0.93]) and
systolic (r2 =0.88, ICC 0.91 [95% CI 0.78,0.96])
volumes on linear regression models. Natural log transformations
eliminated heteroscedasticity, and power transformations provided best
fit. The time (mins) to analyze volumes using VMS were less than using
Tomtec (LV VMS 2.3±0.5, Tomtec 3.3±0.8, p<0.001; LA: VMS
1.9±0.4, Tomtec 3.4±1.0, p<0.001).
Conclusions :
There was very good correlation between knowledge-based (VMS3.0+) and 3D
(Tomtec) algorithms when measuring 3D echocardiography derived LA and LV
volumes in pediatric patients. VMS was slightly faster than Tomtec in
analyzing volumetric measurements.