3. Conclusions
In summary, an 880 nm NIR laser triggered TNPs as PTA for photothermal
therapy of tumor in deep tissue was developed. In this work, a novel
PTA, 3TT-IC-4Cl, was selected and used for PTT, it includes three fused
thieno[3,2-b]thiophene as the central core and difluoro substituted
indanone as the end groups, after encapsulation by
FA-PEG-PBLA10 block copolymer and forming nanoparticles,
the TNPs aqueous solution exhibit strong absorption at 880 nm due to the
π-π stacking. DLS and TEM measurements showed that the TNPs have
spherical shape and narrow size distribution with a mean diameter of 150
nm. These stable nanoparticles are suitable for the EPR effect and
accumulation in the tumor tissue. TNPs exhibit excellent photothermal
stability and high photothermal conversion efficiency after 880 nm laser
irradiation. In the in vitro test, TNPs display excellent
biocompatibility and significant phototoxicity. Therefore, the 880 nm
triggered TNPs has great potential as an effective PTAs for photothermal
therapy of tumor in deep tissue.