Figure 1 Schematic illustration demonstrating of TNPs formation and PTT effect.
Figure 2 1H NMR spectra of (A) TNPs, (B) 3TT-IC-4Cl, and (C) FA-PEG-PBLA10.
Figure 3 (A) TEM image of TNPs, (B) Typical size distributions of TNPs (insert).
Figure 4 (A) UV–Vis absorption spectra of free 3TT-IC-4Cl (red) and TNPs (black), and (B) Fluorescence spectra of free 3TT-IC-4Cl (red) and TNPs (black).
Figure 5 (A) Photothermal conversion behavior of TNPs at different concentrations (0-250 μg/mL) under 880 nm irradiation at 0.7 W/cm2, (B) Photothermal conversion behavior of TNPs at different laser power (0.3-1.5 W/cm2) under 880 nm irradiation at 0.7 W/cm2, and (C) IR thermal images of TNPs at different concentrations (0-250 μg/mL) under 880 nm irradiation at 0.7 W/cm2, and (D) IR thermal images of TNPs at different laser power (0.3-1.5 W/cm2) under 880 nm irradiation at 0.7 W/cm2.
Figure 6 (A) Temperature elevation of TNPs, and free ICG under five irradiation/cooling cycles (under 880 nm irradiation at 0.7 W/cm2 for 5 min), (B) Photographs of the TNPs, and free ICG in PBS solutions after 880 nm light irradiation for different time.
Figure 7 In vitro cytotoxicity test using FA-PEG-PBLA10 and TNPs against HeLa cells (A) dark toxicity depending on the nanoparticles concentration and (B) phototoxicity depending on nanoparticles concentration.