Bullet points:
What is already known: Ginsenosides, one of the major bioactive
constituents of Panax ginseng, have been extensively used due to
their diverse beneficial effects on healthy subjects and patients with
different diseases.
What this study adds: Total ginsenosides enhances mitochondrial
respiration capacity, ATP production and promotes
NAD+-dependent SIRT1 activation to increase
mitochondrial biosynthesis in cardiomyocytes and neurons. Rg1, Re, Rf,
Rb1, Rc, Rh1, Rb2, and Rb3 are major ginsenoside monomers for SIRT1
activation and enhanced energy metabolism.
Clinical significance: This study may provide new insights into
the extensive application of ginseng for cardiac and neurological
protection in healthy subjects and patients with ischemic disorders.