Introduction
The COVID-19 pandemic is a major health issue and patients with underlying conditions are more susceptible to catastrophic outcomes1. Although, this virus mainly involves the pulmonary system, it can also severely affect other organs causing gastrointestinal distress, cardiovascular compromise, acute kidney injury, coagulopathies, cutaneous manifestations and ultimately death from multi-organ failure 2.
Toxic epidermal necrolysis (TEN) is a severe systemic disease caused by immune system hypersensitive reactions characterized by >30% sheet-like epidermal detachment of body surface3. Drug hypersensitivity is responsible for 85–90% of cases of TEN 3. The main manifestations of TEN are mucoucutaneous but multiple organs, such as trachea, bronchi, lungs, etc., are also involved. The mortality rate of TEN ranges from 25% to 30% that makes it the most critical dermatologic emergency3. Here we present a case of TEN that later complicated with COVID-19, Deep Vein Thrombosis (DVT), Pulmonary Embolism, and death.