Introduction
The COVID-19 pandemic is a major health issue and patients with
underlying conditions are more susceptible to catastrophic outcomes1. Although, this virus mainly involves the pulmonary
system, it can also severely affect other organs causing
gastrointestinal distress, cardiovascular compromise, acute kidney
injury, coagulopathies, cutaneous manifestations and ultimately death
from multi-organ failure 2.
Toxic epidermal necrolysis (TEN) is a severe systemic disease caused by
immune system hypersensitive reactions characterized by
>30% sheet-like epidermal detachment of body surface3. Drug hypersensitivity is responsible for 85–90%
of cases of TEN 3. The main manifestations of TEN are
mucoucutaneous but multiple organs, such as trachea, bronchi, lungs,
etc., are also involved. The mortality rate of TEN ranges from 25% to
30% that makes it the most critical dermatologic emergency3. Here we present a case of TEN that later
complicated with COVID-19, Deep Vein Thrombosis (DVT), Pulmonary
Embolism, and death.