Introduction
Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE),
previously known as “Baboon Syndrome,” is a relatively uncommon skin
diagnosis caused by systemic drug exposure and diagnosed if four or more
of the following criteria are met: symmetry, involvement of at least one
intertriginous zone, erythema of the gluteal, inguinal, or axillary
region, systemic exposure to a drug, and lack of systemic
toxicity.1 We present a case after exposure to
tacrolimus after pediatric hematopoietic stem cell transplantation
(HSCT) where other skin conditions, most notably, acute skin graft
versus host disease (GvHD), are often considered and treated in the
differential diagnosis of skin rash.