Introduction
Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), previously known as “Baboon Syndrome,” is a relatively uncommon skin diagnosis caused by systemic drug exposure and diagnosed if four or more of the following criteria are met: symmetry, involvement of at least one intertriginous zone, erythema of the gluteal, inguinal, or axillary region, systemic exposure to a drug, and lack of systemic toxicity.1 We present a case after exposure to tacrolimus after pediatric hematopoietic stem cell transplantation (HSCT) where other skin conditions, most notably, acute skin graft versus host disease (GvHD), are often considered and treated in the differential diagnosis of skin rash.