3.7. Antibody avidity
Antibody avidity reflected the bonding degree of the antigen and the antibodies, and the induction of immunological memory. As indicated in Fig. 3F, ORF8-CRM, ORF8-PEG and ORF8/AL all showed higher AI of the ORF8-specific IgG than that of the ORF8 group (0.65) (P<0.05). In particular, the ORF8-PEG group showed the highest AI value (1.20) of the four samples, indicating that self-conjugation with ORF8 significantly increased the avidity of the ORF8-specific IgG.