3.7. Antibody avidity
Antibody avidity reflected the bonding degree of the antigen and the
antibodies, and the induction of immunological memory. As indicated in
Fig. 3F, ORF8-CRM, ORF8-PEG and ORF8/AL all showed higher AI of the
ORF8-specific IgG than that of the ORF8 group (0.65)
(P<0.05). In particular,
the ORF8-PEG group showed the highest AI value (1.20) of the four
samples, indicating that self-conjugation with ORF8 significantly
increased the avidity of the ORF8-specific IgG.