3.9. Toxicity study
CK and LDH indicated the cardiac function; ALT, TP and ALB indicated the
hepatic function; UA indicated the renal function. The potential
toxicity of ORF8-CRM and ORF-PEG to the cardiac, liver and renal
functions of mice was evaluated by measuring these substances in the
mice sera. As shown in Table 1, the PBS group displayed certain levels
of these substances. As compared with the PBS group, the ORF8 group
exhibited no significant differences in these parameters, except a
slightly high ALB level; the ORF8-CRM and ORF8/AL groups exhibited no
apparent differences except a slightly low LDH and CK levels. These
parameters of the ORF8-PEG group were comparable to those of the PBS
group. Thus, ORF8-CRM and ORF8-PEG showed no apparent toxicity to
the cardiac, liver and renal
functions of mice.