Introduction
Yolk‐sac tumor (YST) is a germ cell tumor subtype that occurs in newborns and infants, as well as young adults aged 14–44 years. It is rarely found primarily in the extragonadal sites with no involvement of the gonads1. We describe a case of primary maxillofacial YST refractory to radiotherapy of the head and neck and various cycles of systemic chemotherapy in a patient with restricted mouth opening. Currently, no cases of induction of anesthesia in children with YST have been reported. This report could help bolster the knowledge of anesthesiologists dealing with these uncommon tumors.