Table 1: Baseline characteristics.
AMICA 2019 AMICA 2019 CAMERA-MRI 2017 CAMERA-MRI 2017 Jones et al. 2013 Jones et al. 2013 CAMTAF 2013 CAMTAF 2013 AATAC 2016 AATAC 2016 CABANA 2021 CABANA 2021 CASTLE-AF 2018 CASTLE-AF 2018 RAFT-AF 2022 RAFT-AF 2022
Ablation arm Medical Therapy Ablation arm Medical Therapy Ablation arm Medical Therapy Ablation arm Medical Therapy Ablation arm Medical Therapy Ablation arm Medical Therapy Ablation arm Medical therapy Ablation arm Medical therapy
Mean age (years) 65 ± 8 65 ± 8 59 ± 11 62 ± 9 64 ± 10 62 ± 9 55 ± 12 60 ± 10 62 ± 10 60 ± 11 68 ± 8 67 ± 8 64 64 66 ± 9 68 ± 8.0
Female gender 8 (12%) 6 (8%) 2 (6%) 4 (12%) 5 (19%) 2 (8%) 1 (4%) 1 (4%) 25 (25%) 27 (27%) 171 (45%) 174 (44%) 23 (13%) 29 (16%) 57 (27%) 49 (25%)
No. of patients 68 72 33 33 26 26 26 24 102 101 378 400 179 184 214 197
Follow up (months) 12 12 6 6 12 12 12 6 24 24 48.5 48.5 37.6 ± 20.4 37.4 ± 17.7 24 24
Persistent AF 100% 100% 100% 100% 100% 100% 100% 100% 100% 100% 71% %66 70% 65% 91% 94%
NYHA class II & III II & III II-IV II-IV II & III II & III II & III II & III II & III II & III II - IV II - IV I-IV I-IV II & III II & III
ICM 44% 56% 0 0 38% 27% 23% 29% 62% 65% N/A N/A 40% 52% 35% 28%
NICM 56% 44% 100% 100% 62% 73% 77% 71% 38% 35% N/A N/A 60% 48% 65% 72%
LVEF % 27.8 ± 9.5 24.8 ± 8.8 32 ± 9.4 34 ± 7.8 22 ± 8 25 ± 7 31.8 ± 7.7 33.7 ± 12.1 29 ± 5 30 ± 8 55 ± 7.4 56 ± 8.9 32.5 ± 9.6 31.5 ± 7.4 41 ± 7.7 40.3 ± 8.4
LA diameter (mm) 50 ± 6 51 ± 5 48 ± 5.5 47 ± 8.2 50 ± 6 47 ± 7 52 ± 11 50 ± 10 47 ± 4 48 ± 5 N/A N/A 48 49.5 46.1 ± 6.0 46.8 ± 5.4
6 min walk distance (meters) 316 ±109 332 ±137 491± 147 489 ± 132 416 ± 78 411 ± 109 N/A N/A 348 ± 111 350 ± 130 N/A N/A N/A N/A 344 ± 107 363 ± 101
Quality of life 38 ±21 36 ±22 N/A N/A 42 ± 23 49 ± 21 N/A N/A 52 ± 24 50 ± 27 AFEQT 58 ± 20 AFEQT 58 ± 20 N/A N/A N/A N/A
Diabetes Mellitus 35% 31% 12% 15% N/A N/A N/A N/A 22% 24% 26% 25% 24% 36% 29% 33%
HTN 82% 76% 39% 36% N/A N/A 30% 33% 45% 48% 84% 87% 72% 74% 65% 67%
CAD N/A N/A N/A N/A 42% 50% N/A N/A 62% 65% 21% 23% N/A N/A 30% 23%
AF: Atrial fibrillation, CAD: Coronary artery disease, NYHA: New York Heart Association, LVEF: left ventricular ejection fraction, LA: left atrial, HTN: Hypertension, ICM: Ischemic cardiomyopathy, NICM: Non-ischemic cardiomyopathy, AFEQT: AF Effect on Quality of Life, N/A: Not available. AF: Atrial fibrillation, CAD: Coronary artery disease, NYHA: New York Heart Association, LVEF: left ventricular ejection fraction, LA: left atrial, HTN: Hypertension, ICM: Ischemic cardiomyopathy, NICM: Non-ischemic cardiomyopathy, AFEQT: AF Effect on Quality of Life, N/A: Not available. AF: Atrial fibrillation, CAD: Coronary artery disease, NYHA: New York Heart Association, LVEF: left ventricular ejection fraction, LA: left atrial, HTN: Hypertension, ICM: Ischemic cardiomyopathy, NICM: Non-ischemic cardiomyopathy, AFEQT: AF Effect on Quality of Life, N/A: Not available. AF: Atrial fibrillation, CAD: Coronary artery disease, NYHA: New York Heart Association, LVEF: left ventricular ejection fraction, LA: left atrial, HTN: Hypertension, ICM: Ischemic cardiomyopathy, NICM: Non-ischemic cardiomyopathy, AFEQT: AF Effect on Quality of Life, N/A: Not available. AF: Atrial fibrillation, CAD: Coronary artery disease, NYHA: New York Heart Association, LVEF: left ventricular ejection fraction, LA: left atrial, HTN: Hypertension, ICM: Ischemic cardiomyopathy, NICM: Non-ischemic cardiomyopathy, AFEQT: AF Effect on Quality of Life, N/A: Not available. AF: Atrial fibrillation, CAD: Coronary artery disease, NYHA: New York Heart Association, LVEF: left ventricular ejection fraction, LA: left atrial, HTN: Hypertension, ICM: Ischemic cardiomyopathy, NICM: Non-ischemic cardiomyopathy, AFEQT: AF Effect on Quality of Life, N/A: Not available. AF: Atrial fibrillation, CAD: Coronary artery disease, NYHA: New York Heart Association, LVEF: left ventricular ejection fraction, LA: left atrial, HTN: Hypertension, ICM: Ischemic cardiomyopathy, NICM: Non-ischemic cardiomyopathy, AFEQT: AF Effect on Quality of Life, N/A: Not available. AF: Atrial fibrillation, CAD: Coronary artery disease, NYHA: New York Heart Association, LVEF: left ventricular ejection fraction, LA: left atrial, HTN: Hypertension, ICM: Ischemic cardiomyopathy, NICM: Non-ischemic cardiomyopathy, AFEQT: AF Effect on Quality of Life, N/A: Not available. AF: Atrial fibrillation, CAD: Coronary artery disease, NYHA: New York Heart Association, LVEF: left ventricular ejection fraction, LA: left atrial, HTN: Hypertension, ICM: Ischemic cardiomyopathy, NICM: Non-ischemic cardiomyopathy, AFEQT: AF Effect on Quality of Life, N/A: Not available. AF: Atrial fibrillation, CAD: Coronary artery disease, NYHA: New York Heart Association, LVEF: left ventricular ejection fraction, LA: left atrial, HTN: Hypertension, ICM: Ischemic cardiomyopathy, NICM: Non-ischemic cardiomyopathy, AFEQT: AF Effect on Quality of Life, N/A: Not available. AF: Atrial fibrillation, CAD: Coronary artery disease, NYHA: New York Heart Association, LVEF: left ventricular ejection fraction, LA: left atrial, HTN: Hypertension, ICM: Ischemic cardiomyopathy, NICM: Non-ischemic cardiomyopathy, AFEQT: AF Effect on Quality of Life, N/A: Not available. AF: Atrial fibrillation, CAD: Coronary artery disease, NYHA: New York Heart Association, LVEF: left ventricular ejection fraction, LA: left atrial, HTN: Hypertension, ICM: Ischemic cardiomyopathy, NICM: Non-ischemic cardiomyopathy, AFEQT: AF Effect on Quality of Life, N/A: Not available. AF: Atrial fibrillation, CAD: Coronary artery disease, NYHA: New York Heart Association, LVEF: left ventricular ejection fraction, LA: left atrial, HTN: Hypertension, ICM: Ischemic cardiomyopathy, NICM: Non-ischemic cardiomyopathy, AFEQT: AF Effect on Quality of Life, N/A: Not available. AF: Atrial fibrillation, CAD: Coronary artery disease, NYHA: New York Heart Association, LVEF: left ventricular ejection fraction, LA: left atrial, HTN: Hypertension, ICM: Ischemic cardiomyopathy, NICM: Non-ischemic cardiomyopathy, AFEQT: AF Effect on Quality of Life, N/A: Not available. AF: Atrial fibrillation, CAD: Coronary artery disease, NYHA: New York Heart Association, LVEF: left ventricular ejection fraction, LA: left atrial, HTN: Hypertension, ICM: Ischemic cardiomyopathy, NICM: Non-ischemic cardiomyopathy, AFEQT: AF Effect on Quality of Life, N/A: Not available. AF: Atrial fibrillation, CAD: Coronary artery disease, NYHA: New York Heart Association, LVEF: left ventricular ejection fraction, LA: left atrial, HTN: Hypertension, ICM: Ischemic cardiomyopathy, NICM: Non-ischemic cardiomyopathy, AFEQT: AF Effect on Quality of Life, N/A: Not available. AF: Atrial fibrillation, CAD: Coronary artery disease, NYHA: New York Heart Association, LVEF: left ventricular ejection fraction, LA: left atrial, HTN: Hypertension, ICM: Ischemic cardiomyopathy, NICM: Non-ischemic cardiomyopathy, AFEQT: AF Effect on Quality of Life, N/A: Not available.