Author contribution
YW, YT and IN were involved in the clinical management. YW wrote the
manuscript. IN and HW was involved in the revision of the manuscript.
All authors approved the final version for submission.
1. Albibi R, McCallum RW. Metoclopramide: pharmacology and clinical
application. Ann Intern Med 98(1):86-95, 1983.
2. Hesketh PJ, Kris MG, Basch E, et al. Antiemetics: ASCO Guideline
Update. J Clin Oncol 38(24):2782-2797, 2020.
3. Gan TJ, Belani KG, Bergese S, et al. Fourth Consensus Guidelines for
the Management of Postoperative Nausea and Vomiting. Anesth Analg
131(2):411-448, 2020.
4. Tisdale JE, Chung MK, Campbell KB, et al. Drug-Induced Arrhythmias: A
Scientific Statement From the American Heart Association. Circulation
142(15):e214-e233, 2020.
5. Drew BJ, Ackerman MJ, Funk M, et al. Prevention of torsade de pointes
in hospital settings: a scientific statement from the American Heart
Association and the American College of Cardiology Foundation.
Circulation 121(8):1047-1060, 2010.
6. Bor S, Demir M, Ozdemir O, Yuksel K. A meta-analysis on the cardiac
safety profile of domperidone compared to metoclopramide. United
European Gastroenterol J 6(9):1331-1346, 2018.
7. Sarganas G, Garbe E, Klimpel A, Hering RC, Bronder E, Haverkamp W.
Epidemiology of symptomatic drug-induced long QT syndrome and Torsade de
Pointes in Germany. Europace 16(1):101-108, 2014.
8. Wolfes J, Ellermann C, Burde S, Fehr M, Eckardt L, Frommeyer G.
Proarrhythmic potential of metoclopramide in a sensitive whole-heart
model. Basic Clin Pharmacol Toxicol 128(6):741-746, 2021.
9. Ellidokuz E, Kaya D. The effect of metoclopramide on QT dynamicity:
double-blind, placebo-controlled, cross-over study in healthy male
volunteers. Aliment Pharmacol Ther 18(1):151-155, 2003.
10. Chou CC, Wu D. Torsade de pointes induced by metoclopramide in an
elderly woman with preexisting complete left bundle branch block. Chang
Gung Med J 24(12):805-809, 2001.
11. Siddique SM, Shariff N, Vesuwala N, Hafiz T. Metoclopramide as a
possible cause of prolonged QT syndrome and torsade de pointes in a
patient with heart failure and renal insufficiency. In: Ann Intern Med.
United States, 2009:502-504.
12. Gnanapandithan K, Karthik N, Gerber J. Methadone, Metoclopramide and
Metronidazole Interaction Causing Torsades de Pointes. In: Clin Pract.
2021:101-105.