LEGENDS

Figure 1. Flow chart of the whole study
Figure 2. Risk factors for osteonecrosis. Multivariate analysis.
2A . All patients
2B. SCT patients
2C. Patients without SCT
Being over 10 years old when diagnosed with leukemia is associated with a greater occurrence of ON, as well as suffering from relapse due to prolonged treatment. Girls were also often affected, except in the SCT group.
Figure 3. Evaluation of quality of life in patients with osteonecrosis.
3A. Comparison of adult quality of life with the general population and L.E.A cohort, according to SF-36 score
Comparing to general population, adults have a significant loss in physical global score, social functioning (p < 0.001) and emotional global score (p< 0.001). This negative impact is also shown when compared with patients of L.E.A cohort, except for mental health and emotional scores.