Statistical analysis
All data are presented as mean ± SEM (standard error of the mean). GraphPad Prism was used to compare two groups using Unpaired Student’s t-tests and one-way ANOVA followed by Tukey’s post hoc test for comparing multiple groups using one-way ANOVA (Version 8.0.1), and statistically significant differences are indicated as follows: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.