Introduction:
Plasma that constitutes more than half of the circulating extracellular
volume is of utmost importance in sustaining life. But the fact to be
understood here is that even such a vital component has got ironical
characteristics of its own. These are undeniably true in case of
peptides in the blood which culminates both peptides and peptidases side
by side. This we mean for the kinins in plasma which are ubiquitous
throughout with kininases alongside. Even though their absolute roles
are yet to be established their definitive roles are brought to light by
the extensive research which is being done today. This has become an
area of interest in the recent years in the fields of physiology,
pharmacology, pathology and therapeutics. This review narrates about the
kinins commencing from their discovery to their physiological roles and
its implications in drug development, and tries to analyse the most
noted part which is the failures that overshadows the drug development
in case of kinins.