Bradykinins:
The role of bradykinin in various disease states is undisputable. Studies in a mouse strain with targeted disruption of the BK2 receptor gene have given important new insights into the role of the kallikrein/kinin system in the pathogenesis of hypertension and heart failure.27 Neuropathic pain is a leading debilitating morbidity resulting from Spinal Cord Injury, and it remains an unmet medical demand. In a rat model of contusion SCI, more than twofold increase was observed for the expression of B1BKR and vanilloid-1 (TRPV-1) receptor genes in the injured segment dorsal horn region of the spinal cord in rats manifesting hyperalgesia behaviour compared with SCI rats that did not show hyperalgesia.28 Bradykinin may be a competitive substrate of DPP-4, and decreased bradykinin levels may enhance protective effects against ischemia/reperfusion injury during Leukotrienes.29 There is a well-established role of Bradykinin in Hereditary angioedema and some forms of acquired angioedema which are especially due to increased bradykinin levels.30 For pathophysiology of hereditary angioneurotic oedema refer figure 3 appendix 2