Conclusion
With this comprehensive review it is evident these kinins have important
role in homeostatic functions of the body physiologically. Again, the
pathophysiological roles in inflammation and most important being
sustainability of inflammation rather than inciting itself is evident.
These makes them a potential target for drug development and the drugs
developed were extensively discussed and the failures with respective
clinical trials. The complexity of these systems and interconnections
are evident and sounds like we are still “scratching the surface” of a
complicated puzzle. The time to explore the complexity and fit the
puzzle would be in the near future with advancements in the field of
research day by day. Still, this seems to be an evolving science and an
area to be explored to pave a way for upcoming drug discoveries.