Tachykinins:
Many types of tumour cells express NKRs, and tachykinins from tumour cells or infiltrating nerves or immune cells can influence proliferation, apoptosis, and metastasis of tumour cells in an autocrine, paracrine, or neurocrine manner.31,32, 33In case of pulmonary diseases that affect the lungs by inducing inflammation substance P has a substantial role as elucidated by various animal studies.34 SP stimulates the generation and release of cytokines, chemokines, matrix metalloproteases, and ROS from neutrophils thus playing a major role in inflammation.35,36 Tachykinins also stimulate secretion from airway seromucous glands thus plays an important role in airway inflammation.37 The role of tachykinins in Post operative nausea and vomiting is undisputable and the respective antagonists are highly effective in treatment and prevention of this aspect.38