Conclusion
With this comprehensive review it is evident these kinins have important role in homeostatic functions of the body physiologically. Again, the pathophysiological roles in inflammation and most important being sustainability of inflammation rather than inciting itself is evident. These makes them a potential target for drug development and the drugs developed were extensively discussed and the failures with respective clinical trials. The complexity of these systems and interconnections are evident and sounds like we are still “scratching the surface” of a complicated puzzle. The time to explore the complexity and fit the puzzle would be in the near future with advancements in the field of research day by day. Still, this seems to be an evolving science and an area to be explored to pave a way for upcoming drug discoveries.