Tachykinins:
Many types of tumour cells express NKRs, and tachykinins from tumour
cells or infiltrating nerves or immune cells can influence
proliferation, apoptosis, and metastasis of tumour cells in an
autocrine, paracrine, or neurocrine manner.31,32, 33In case of pulmonary diseases that affect the lungs by inducing
inflammation substance P has a substantial role as elucidated by various
animal studies.34 SP stimulates the generation and
release of cytokines, chemokines, matrix metalloproteases, and ROS from
neutrophils thus playing a major role in
inflammation.35,36 Tachykinins also stimulate
secretion from airway seromucous glands thus plays an important role in
airway inflammation.37 The role of tachykinins in Post
operative nausea and vomiting is undisputable and the respective
antagonists are highly effective in treatment and prevention of this
aspect.38