Bradykinins:
The role of bradykinin in various disease states is undisputable.
Studies in a mouse strain with targeted disruption of the
BK2 receptor gene have given important new insights into
the role of the kallikrein/kinin system in the pathogenesis of
hypertension and heart failure.27 Neuropathic pain is
a leading debilitating morbidity resulting from Spinal Cord Injury, and
it remains an unmet medical demand. In a rat model of contusion SCI,
more than twofold increase was observed for the expression of B1BKR and
vanilloid-1 (TRPV-1) receptor genes in the injured segment dorsal horn
region of the spinal cord in rats manifesting hyperalgesia behaviour
compared with SCI rats that did not show
hyperalgesia.28 Bradykinin may be a competitive
substrate of DPP-4, and decreased bradykinin levels may enhance
protective effects against ischemia/reperfusion injury during
Leukotrienes.29 There is a well-established role of
Bradykinin in Hereditary angioedema and some forms of acquired
angioedema which are especially due to increased bradykinin
levels.30 For pathophysiology of hereditary
angioneurotic oedema refer figure 3 appendix 2