6.2.2 Theiler’s virus-induced TLE
After intracortical injections of TMEV or PBS, C57Bl/6 mice were monitored for acute seizures. Between days 3 and 7 after infection (dpi), mice infected with TMEV exhibited behavioural seizures. Most seizures were stage 4 or 5 on the modified Racine scale [Figure 2] at six days post-induction as the severity of the seizures grew over time. The biochemical tests were performed on mice that had experienced at least one seizure throughout the observation period. At 3-, 4-, and 14-days post-inoculation GSH levels in TMEV-infected mice were dramatically decreased and concurrently GSSH levels rose and the redox status was compromised. This study is the first to show that the TMEV model of infection-induced TLE experiences oxidative stress