6.1.5 Tetanus toxin-induced TLE
A chronic model of temporal lobe epilepsy (TLE) marked by intermittent
spontaneous seizures beginning after a latent period of around seven
days is provided by intrahippocampal TeNT [50]. The TeNT
model is distinct from other spontaneously seizing Rat TLE models,
lacking early status epilepticus (prolonged epileptic seizures). It
causes little to no neuronal death in 70–90% of instances while
producing highly localized lesions in the remaining cases.
Advantages: The teNT model can be utilized to develop a
chronic TLE model with sporadic spontaneous seizures. This Model shows
how TLE develops and progresses.
Disadvantages: Tetanus toxin affects the brain by destroying
inhibitory synapses. Even though it sheds light on the pathophysiology
of epilepsy, this complicated system may not adequately encompass the
various mechanisms causing various forms of epilepsies.