6.1.4 Penicillin-Induced TLE
Sherdil A. et al. conducted a study where the hippocampus was injected with penicillin in each experiment, and the animals were watched for five hours straight. A mean cumulative dose of >16000 IU of penicillin was administered over 98 to 276 days, and injections were repeated at least once weekly [49]. The seizure severity was assessed with the help of Modified Racine scale [Figure 2]
Advantages: This Model can change from a chronic model with spontaneous seizures following accumulative penicillin injections to an on-demand model with on-demand seizures.
Disadvantages: Repeated penicillin injections and stereotaxic insertion of deep recording electrodes are intrusive, difficult procedures.