5.1.1 Pilocarpine Induced Model
Pilocarpine-induced status epilepticus (SE) is a frequently used mouse
seizure model. The study by Phelan KD et al. sheds essential light on
the intricate link between seizure behaviours and EEG activity at
various stages of pilocarpine-induced epileptic seizures. Pilocarpine is
injected at a dose of 100-400 mg/kg Intraperitoneally, and the animals
exhibit prolonged seizure activity without regaining consciousness in
between. To understand seizure dynamics thoroughly, it uses modified
Racine scale [Figure 2] in determining seizure strength during the
SE stage. It also emphasizes the necessity of adding EEG data[44] . Table 4.
Advantages: The relationship between EEG and seizure activity
can be very well correlated by this model.
Disadvantages: Although fast Fourier transformation (FFT) is
helpful for EEG research, it may also be challenging and complicated
for interpretation.