6.1.1 KA-Induced TLE
KA is an ionotropic KA receptor agonist and a cyclic analog of L-glutamate. Acute seizures are characterized by symptoms comparable to those seen after intrahippocampal injections following intra-amygdaloid injections of KA (0.4-2 g) in rats [46] . In monkeys, however, intracerebral administration of KA (0.5-10 μg/μl of saline) in the hippocampus or the amygdala does not produce generalized seizures but is linked to focal seizures.
Advantages: The main benefit of administering KA systemically instead of intracerebrally is that more animals can be injected simultaneously with fewer complications.
Disadvantages: The way different species react to KA treatment can differ. This calls into doubt the Model’s applicability to epilepsy in humans.