Patients
In the multicenter clinical trial CoALL08-09 accrual was open from 1 October 2010 to 31 December 2019. A total of 745 patients aged >1 and < 18 years were enrolled in 8 cooperating trial centers in Germany. The study was approved by the ethics committee of the city of Hamburg and the institutional review boards of every individual trial center. Written informed consent was obtained from patients’ parents or guardians in each case. The trial was registered at the ClinicalTrials.gov data base: GPOH-COALL 08-09 EU-21076 /NCT 0122 8331.