Statistical analysis
Normally distributed variables were expressed as mean ± standard
deviation (SD), while median (range) or median (interquartile range) was
used to describe skewed variables. To compare the repeated measured data
of the RIF and ATO groups, linear mixed model was used. Mann-Whitney U
test were used for skewed data to compare between groups while two
independent samples t test for normally distributed data. The comparison
between Dichotomous variables was evaluated by the Chi-square
(χ2) test. ROC curve was used to define the cutoff
values. IBM SPSS Statistics 21.0 was used for all statistical analysis.