Statistical analysis
Normally distributed variables were expressed as mean ± standard deviation (SD), while median (range) or median (interquartile range) was used to describe skewed variables. To compare the repeated measured data of the RIF and ATO groups, linear mixed model was used. Mann-Whitney U test were used for skewed data to compare between groups while two independent samples t test for normally distributed data. The comparison between Dichotomous variables was evaluated by the Chi-square (χ2) test. ROC curve was used to define the cutoff values. IBM SPSS Statistics 21.0 was used for all statistical analysis.