Laboratory studies
The dynamic change of WBC and coagulation indexes including PLT, prothrombin time (PT), activated partial thromboplastin time (APTT), D-Dimer and Fbg were collected on the first day of visit (day 0) and after induction treatment (around day 4, 7, 10, 13, 16, 19, 22, 25 and 28). The percentage of promyelocyte in the bone marrow and peripheral blood were determined by microscopic examination by two experienced physicians independently. Minimal residual disease (MRD) was monitored by qRT-PCR for detection of PML-RARα fusion gene.