The Risk Factors for Differentiation-Related Hyperleukocytosis
and DS
Patients with higher WBC counts or higher percentage of promyelocytes in
peripheral blood tended to develop differentiation-related
hyperleukocytosis (Table 2). As expected, moderate and severe DS
occurred in 10.3% and 0% of patients with and without the
differentiation-related hyperleukocytosis respectively (p =
0.040) (Table 2). Those patients who developed hyperleukocytosis have
higher MRD after induction treatment (p = 0.013) (Table 2). High
WBC at admission and high percentage of promyelocyte in peripheral blood
were the risk factors predicting the development of hyperleukocytosis,
with the cut-off values of 2.61×109/L and 26.5%
respectively (Tables 2 and 3).