The Recovery of Coagulopathy
The recovery of coagulopathy was not statistically different between the
ATO and RIF groups except for higher values of D-Dimer on day 12-14 in
the RIF groups (p< 0.05) (Fig. 3 and Supplemental Table S1).
In general, PT and Fbg recovered on day 3-5. PLT and D-Dimer levels
needed longer time to recover. At weeks 1, 3 and 4, PLT returned to
normal value (100×109/L) in 2.9%, 48.5% and 94.1%
of the patients, and D-Dimer in 2.9%, 44.1% and 80.9% of the
patients, respectively.
The incidences of bleeding and thrombus events were not statistically
different between the ATO and RIF groups (Supplemental Table S2). There
were 11 (33.3%) and 12 (34.3%) patients requiring heparin treatment in
the ATO and RIF groups according to the judgment of clinicians
respectively. In addition, the amount of platelets, plasma, and
cryoprecipitate used was not statistical difference between the two
groups (Supplemental Table S3).