Definition of Differentiation-Related Hyperleukocytosis and WBC Normalized Value
According to our previous study 1, differentiation-related hyperleukocytosis is defined as: WBC > 10 x 109/L in NHR group, and the maximum of WBC increases by over 30% compared with that at diagnosis (day 0) in HR group during induction treatment. To make the WBC data among patients comparable, the WBC counts have been normalized as the ratio between WBC on day X to WBC on day 0. Using this method of normalization, the WBC at day 0 would be 1 for all patients. The calculation formula is: WBC normalized value =\(\frac{WBC\ (day\ X)}{WBC\ (day\ 0)}\) .