The Risk Factors for Differentiation-Related Hyperleukocytosis and DS
Patients with higher WBC counts or higher percentage of promyelocytes in peripheral blood tended to develop differentiation-related hyperleukocytosis (Table 2). As expected, moderate and severe DS occurred in 10.3% and 0% of patients with and without the differentiation-related hyperleukocytosis respectively (p = 0.040) (Table 2). Those patients who developed hyperleukocytosis have higher MRD after induction treatment (p = 0.013) (Table 2). High WBC at admission and high percentage of promyelocyte in peripheral blood were the risk factors predicting the development of hyperleukocytosis, with the cut-off values of 2.61×109/L and 26.5% respectively (Tables 2 and 3).