The Recovery of Coagulopathy
The recovery of coagulopathy was not statistically different between the ATO and RIF groups except for higher values of D-Dimer on day 12-14 in the RIF groups (p< 0.05) (Fig. 3 and Supplemental Table S1). In general, PT and Fbg recovered on day 3-5. PLT and D-Dimer levels needed longer time to recover. At weeks 1, 3 and 4, PLT returned to normal value (100×109/L) in 2.9%, 48.5% and 94.1% of the patients, and D-Dimer in 2.9%, 44.1% and 80.9% of the patients, respectively.
The incidences of bleeding and thrombus events were not statistically different between the ATO and RIF groups (Supplemental Table S2). There were 11 (33.3%) and 12 (34.3%) patients requiring heparin treatment in the ATO and RIF groups according to the judgment of clinicians respectively. In addition, the amount of platelets, plasma, and cryoprecipitate used was not statistical difference between the two groups (Supplemental Table S3).