Definition of Differentiation-Related Hyperleukocytosis and WBC
Normalized Value
According to our previous study 1,
differentiation-related hyperleukocytosis is defined as: WBC
> 10 x 109/L in NHR group, and the
maximum of WBC increases by over 30% compared with that at diagnosis
(day 0) in HR group during induction treatment. To make the WBC data
among patients comparable, the WBC counts have been normalized as the
ratio between WBC on day X to WBC on day 0. Using this method of
normalization, the WBC at day 0 would be 1 for all patients. The
calculation formula is: WBC normalized value =\(\frac{WBC\ (day\ X)}{WBC\ (day\ 0)}\) .