RESULTS
The patients characteristics of medicine abortion were listed in Table
1, including age, body weight, gestational age, gestational sac
diameter, pregnancy history, cesarean section history and miscarriage
history. Genotype frequencies were in Hardy-Weinberg equilibrium for
MDR1 C3435T, MDR1 C1236T, MDR1 G2677T/A and CYP3A4*1G.
We examined the contribution of dose exposure on the efficacy and
adverse reaction of mifepristone. As shown in Table 2, the blood
concentration of both mifepristone and monodemethyl-mifepristone was
higher in patients with successful outcome than that in patients with
failed outcome (P = 0.031 and 0.012, respectively), as well as
C/D of mifepristone and monodemethyl-mifepristone (P = 0.040 and
0.017, respectively). In addition, the incidence of adverse reaction was
associated with a higher concentration of mifepristone as well as C/D of
mifepristone (P = 0.010 and 0.008, respectively).
For gene polymorphisms of MDR1, there was no association between C3435T,
C1236T and the blood concentration of both mifepristone and
monodemethyl-mifepristone. Whereas, G2677T/A was
associated
significantly with the blood concentration of mifepristone as well as
monodemethyl-mifepristone (P = 0.012 and 0.004, respectively).
The patients carried CYP3A4A*1G allele have a lower concentration of
mifepristone compared with patients that carried wild type (P =
0.012). There was no relationship between CYP3A4A*1G and the blood
concentration of monodemethyl-mifepristone (P = 0.747) (Table 3).
Table 4 and Table 5 showed the relationship of gene polymorphisms of
MDR1 and CYP3A4 with the efficacy and adverse reaction of mifepristone.
It is showed that the successful outcome of mifepristone was not
affected by MDR1 C3435T and C1236T (P = 0.345 and 0.385,
respectively). For MDR1 G2677T/A, the patients carried wild type had a
higher incident of successful outcome than that carried mutant type
(P = 0.042). There was no association between CYP3A4 *1G and the
effecacy of mifepristone (P = 0.827). In addition, there was also
no significant association among the MDR1 C3435T, C1236T and CYP3A4 *1G
and the adverse reaction of mifepristone (P = 0.677, 0.472 and
0.919, respectively). The adverse reaction of mifepristone was affected
by MDR1 G2677T/A (P = 0.000).