Outcome Data Sources
Summary-level data for OC were obtained from the Ovarian Cancer
Association Consortium (OCAC), which involved 25,509 cases of overall OC
and 40,941 controls of European descent [31]. In the subtype
analyses, the data included 7 well classified OC histotypes: High grade
serous (HGSOC, 13,037 cases and 53,978 controls), Low grade serous
(LGSOC, 1,012 cases and 41,953 controls), Invasive mucinous (IMOC, 1,417
cases and 42,358controls), Endometrioid (EOC, 2,810cases and 43,751
controls), Clear cell (CCOC, 1,366 cases and 42,307 controls), Low
malignant potential serous (LMSOC, 1,954 cases and 42,895 controls), and
Low malignant potential mucinous (LMMOC, 1,149 cases and 42,090
controls). Association tests were adjusted for up to 19 genetic
principal components in the data sources. Data from the consortia were
extracted through the MR-Base platform [32]. Characteristics and
detailed information on used data sources are displayed in Table
S1 . All studies had been approved by a relevant ethical review board
and participants had given informed consent.