Conclusions
In conclusion, our results suggest causal associations of lower
educational attainment and increased coffee or tea consumption, fat
intake, BMI, and smoking with increased risk of OC histological
subtypes. Specifically, our study demonstrated that genetically
determined years of education was inversely associated with overall OC,
and subtypes of LMSOC, HGSOC, IMOC, LGSOC, and EOC. Higher coffee or tea
consumption was causally associated with EOC risk. In addition, we found
increased dietary fat intake was detrimental for HGSOC, but protective
for EOC subtype. Genetic predisposition to a higher BMI was positively
associated with the risk of LMSOC, LMMOC, and EOC. Elevated lifetime
smoking index was suggestively associated with increased risk overall
OC, HGSOC and EOC. Whereas physical activity, sleep duration, insomnia,
and alcohol consumption are not associated with any type of OC. These
findings have major clinical and public health implications as lifestyle
factors can easily be modified. However, the results should be
interpreted with caution considering the difficulty in completely ruling
out pleiotropy.