Figure legends
Figure 1 . Graphical overview of the MR study design. The
Mendelian Randomization (MR) design indicates that the genetic variants
proposed as instrumental variables (IVs) should be robustly associated
with the risk factor of interest; the selected IVs should not be
associated with potential confounders and affect the risk of the outcome
merely through the risk factors, not via alternative pathways. The
genetic variants, selected as IVs for studying the effect of modifying
the exposure, are randomly allocated at conception and are therefore
less vulnerable to confounding from environmental factors and reverse
causation. Multiple analyses are conducted to assess the causal
relationship between lifestyle factors and the risk of ovarian cancer
subtypes.
Figure 2 . Associations of genetically predicted lifestyle
factors and ovarian cancer subtypes. The OR (95% CI) of ovarian cancer
subtypes were estimated using an inverse-variance weighted
meta-analysis.