Literature review and search strategy
A systematic literature search was conducted, including studies up until
May 2021 in the databases MEDLINE (via PubMed), EMBASE (via Scopus), and
the Cochrane Database of Systematic Reviews. We aimed to identify
studies that analyzed how individuals with HFrEF, particularly
pacing-induced cardiomyopathy (PICM), responded to LBBAP implantation.
Two investigators (N.S. and R.C.) separately compiled the systematic
literature review using a search strategy that included the terms “left
bundle branch pacing” and (“heart failure” or “pacing-induced
cardiomyopathy”) (Supplementary 1 ). There were no language
restrictions. Reference lists of recognized studies were manually
searched for relevant research as well. This systematic review and
meta-analysis followed the Meta-analyses Of Observational Studies in
Epidemiology (MOOSE) standards and the Preferred Reporting Items for
Systematic Reviews and Meta-Analyses (PRISMA) statement.