Longitudinal analysis of T cell responses by vaccine brand and route
Longitudinal analysis of IFN-γ+ CD4+and CD8+T cell responses against SARS-CoV-2 S peptide pool in BNT162b2 recipients and S, N and M peptide pools in CoronaVac recipients from baseline to post-dose 3 are shown in Fig. 5A-D. Responses were compared longitudinally between baseline and post-dose 2 by vaccine brand, as well as post-dose 2 with post-dose 3 by paired t test after natural logarithmic transformation. We only found weak increases that were statistically insignificant, except between baseline and post-dose 2 in BNT162b2 recipients for S-specific IFN-γ+ CD4+ T cells (P=0.0064; Fig. 5A). Analysis of IL-2+ CD4+ and CD8+ T cells also yielded similar findings (Supp. Fig. 2A-D). Four patients received an intradermal dose 3 appeared to have a similar distribution with patients who received intramuscular vaccination.