Longitudinal analysis of T cell responses by vaccine brand and
route
Longitudinal analysis of IFN-γ+ CD4+and CD8+T cell responses against SARS-CoV-2 S peptide
pool in BNT162b2 recipients and S, N and M peptide pools in CoronaVac
recipients from baseline to post-dose 3 are shown in Fig. 5A-D.
Responses were compared longitudinally between baseline and post-dose 2
by vaccine brand, as well as post-dose 2 with post-dose 3 by paired t
test after natural logarithmic transformation. We only found weak
increases that were statistically insignificant, except between baseline
and post-dose 2 in BNT162b2 recipients for S-specific
IFN-γ+ CD4+ T cells (P=0.0064; Fig.
5A). Analysis of IL-2+ CD4+ and
CD8+ T cells also yielded similar findings (Supp. Fig.
2A-D). Four patients received an intradermal dose 3 appeared to have a
similar distribution with patients who received intramuscular
vaccination.