3.2 Side effect profile
In order to understand the side effect profile of Asparaginase,
participants were asked multiple-choice questions with options
consisting of various side effects of Asparaginase such as
hypersensitivity reaction, liver dysfunction (hyperbilirubinemia and
transaminitis), hyperglycemia needing medication, cerebral sinus venous
thrombosis, and pancreatitis. Further to this question elaborated the
phase in which side effects were observed (Induction vs
re-induction/delayed intensification), and the type of Asparaginase
utilised. The most common side effect observed by survey participants is
hypersensitivity reaction followed by liver dysfunction. Frequency of
hypersensitivity reaction was more in re-induction (40% in induction
vs. 72% in re-induction with respect to native Asparaginase). As per
the respondents, the frequency of hypersensitive reactions were lesser
with the utility of PEG Asparginase as compared to native formulation,
which was statistically significant (p=0.01). The side effect profile,
route of administration and the dose of Asparaginase (native or
PEGylated) lacked correlation with adverse events. The side effect
profile is presented in Figures 3.