3.2 Side effect profile
In order to understand the side effect profile of Asparaginase, participants were asked multiple-choice questions with options consisting of various side effects of Asparaginase such as hypersensitivity reaction, liver dysfunction (hyperbilirubinemia and transaminitis), hyperglycemia needing medication, cerebral sinus venous thrombosis, and pancreatitis. Further to this question elaborated the phase in which side effects were observed (Induction vs re-induction/delayed intensification), and the type of Asparaginase utilised. The most common side effect observed by survey participants is hypersensitivity reaction followed by liver dysfunction. Frequency of hypersensitivity reaction was more in re-induction (40% in induction vs. 72% in re-induction with respect to native Asparaginase). As per the respondents, the frequency of hypersensitive reactions were lesser with the utility of PEG Asparginase as compared to native formulation, which was statistically significant (p=0.01). The side effect profile, route of administration and the dose of Asparaginase (native or PEGylated) lacked correlation with adverse events. The side effect profile is presented in Figures 3.