Discussion
We reported a case of oral Kaposi’s sarcoma associated with HIV infection and SARS-Cov2.
It is due to HHV-8 infection and is the common malignant skin tumors associated with HIV infection. Its presence reveals an advanced stage of the disease [5].
Since covid 19, several studies have demonstrated the action of SARS Cov 2 on the reactivation of the HHV 8 virus hence the increased prevalence of Kaposi’s sarcoma. They even found that the quality of life of patients with Kaposi’s sarcoma infected with SARS Cov 2 without HIV infection is lower than those infected with HIV [1, 6].
A case of an 83-year-old patient was reported for Kaposi’s sarcoma of the soles of the feet in a patient followed by Covid 19. HIV serology was tested negative [6].
Cancer is closely related to the risk of severe disease and mortality in patients with COVID-19. Cov 2 SARS could promote tumor progression and stimulate metabolic switching in tumor cells to initiate tumor metabolism with high efficiency. On the other hand, SARS Cov 2 has been shown to delay the progression of some cancers such as NK and Hodgkin lymphoma [7]. This may explain the rapid progression of Kaposi’s sarcoma in our case.