Abstract
Nowadays apparently harmless and commensal Candida species
specially, uncommon and rare ones, cause a rising number of infections
although, very rare, but if they aren’t treated, they can become serious
and result in permanent consequences. Candida species can cause
conjunctivitis after trauma and antibiotic therapy to an inflamed eye.Candida metapsilosis is a recently described yeast,
phenotypically indistinguishable from Candida parapsilosis , and
molecular methods are essential for its detection. We report the first
case of Candida conjunctivitis due to Candida metapsilosisobtained from the eye discharge of 40-day-old girl with congenital heart
disease admitted in the cardiac intensive care unit (CICU). The yeast
isolate was identified by traditional and molecular methods such as
PCR-RFLP and sequencing of the entire ITS genomic region (ITS1,
ITS2 and 5.8 rRNA). Antifungal susceptibility test performed according
to the CLSI M27-A3, showed that the isolate was susceptible to
amphotericin B, Itraconazole, voriconazole, clotrimazole, nystatin,
terbinafine, 5-fluorocytosine and caspofungin whereas was resistant to
fluconazole, anidulafungin and micafungin.
Keywords: Candida metapsilosis , pediatrics, uncommon
Candida, Antifungal susceptibility test